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Significance Regulation of stem cells by microenvironment signals is important to maintain epithelial homeostasis. Using a quantitative readout, we screened for receptor genes that affect the intestinal stem cell pool size in the adultDrosophila midgut. The top candidate of our screen,AdoR , underscores the importance of purinergic signaling in controlling ISC activity. Furthermore, we identified a pivotal role of an enterocyte-derived metabolic enzyme, Adgf-A, in limiting the activity of extracellular adenosine and shaping the ISC microenvironment.

An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity