Hippo signaling is intrinsically regulated during cell cycle progression by APC/C Cdh1 | Zendy

Wantae Kim | Zendy; Yong Suk Cho | Zendy; Xiaohui Wang | Zendy; Ogyi Park | Zendy; Xueyan Ma | Zendy; Hanjun Kim | Zendy; Wenjian Gan | Zendy; Eekhoon Jho | Zendy; Boksik Cha | Zendy; Yun-ji Jeung | Zendy; Lei Zhang | Zendy; Bin Gao | Zendy; Wenyi Wei | Zendy; Jin Jiang | Zendy; KyungSook Chung | Zendy; Yingzi Yang | Zendy

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Hippo signaling is intrinsically regulated during cell cycle progression by APC/C ^Cdh1

Author(s) -

Wantae Kim,

Yong Suk Cho,

Xiaohui Wang,

Ogyi Park,

Xueyan Ma,

Hanjun Kim,

Wenjian Gan,

Eekhoon Jho,

Boksik Cha,

Yun-ji Jeung,

Lei Zhang,

Bin Gao,

Wenyi Wei,

Jin Jiang,

KyungSook Chung,

Yingzi Yang

Publication year - 2019

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1821370116

Subject(s) - hippo signaling pathway , microbiology and biotechnology , ubiquitin ligase , biology , cdh1 , kinase , ubiquitin , mitosis , phosphorylation , cell cycle , cell growth , signal transduction , transcription factor , e2f , anaphase promoting complex , cyclin dependent kinase 1 , cell , genetics , cadherin , gene

Significance The Hippo signaling pathway is evolutionarily conserved in the animal kingdom and plays essential roles in regulating tissue growth during development and regeneration. We have identified APC/CCdh1 , a core component of cell cycle control machinery, as an evolutionarily conserved and previously unknown regulator of large tumor suppressor (LATS) kinases, which critically inhibit the YAP/TAZ transcription factors in transducing Hippo signaling. Our results suggest a model that APC/CCdh1 destabilizes LATS1/2 kinases in G1 phase of the cell cycle, leading to increased YAP/TAZ activities that promote G1/S transition by upregulating downstream gene expression, includingE2F1 . Our findings have important implications for a link between cell proliferation and LATS-regulated YAP/TAZ activities.

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