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Significance RNA-directed DNA methylation (RdDM) is an important mechanism in the silencing of transposable elements in plants. The framework of RdDM has been well established, in which DNA polymerase IV (Pol IV) and Pol V act in upstream siRNA biogenesis and downstream DNA methylation, respectively. The DDR complex, consisting of DMS3, DRD1, and RDM1, is responsible for recruiting Pol V, and dysfunction of any of them causes compromised RdDM activity. However, how the association among DMS3, DRD1, and RDM1 is regulated is unexplored. We show here that the anaphase-promoting complex/cyclosome (APC/C), a key cell cycle regulatory complex, regulates the assembly of the DDR complex by targeting DMS3 for degradation, and thereby provide a perspective in understanding the regulatory mechanism of RdDM activity.

Anaphase-promoting complex/cyclosome regulates RdDM activity by degrading DMS3 in Arabidopsis