Open AccessPopulation-level rhythms in human skin with implications for circadian medicine
Author(s) -
Gang Wu,
Marc D. Ruben,
Robert E. Schmidt,
Lauren J. Francey,
David F. Smith,
Ron C. Anafi,
Jacob Hughey,
Ryan Tasseff,
Joseph D. Sherrill,
John E. Oblong,
Kevin J. Mills,
John B. Hogenesch
Publication year - 2018
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1809442115
Subject(s) - circadian rhythm , rhythm , population , chronobiology , medicine , physiology , biology , environmental health
Significance We used a hybrid design combining epidermis samples from both deep phenotyping of 20 individuals and snapshot data from more than 200 other human subjects to find biomarkers of the human circadian phase. Using CYCLOPS to reconstruct the temporal order of all samples, we identified hundreds of genes cycling at population level and found that phase relationships of human skin epidermis output genes are conserved with the mouse skin. Finally, we showed that human epidermis has a stronger clock than blood and developed a panel of biomarkers that can phase individuals to within 3 hours from a single sample.
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