Glutamate-activated BK channel complexes formed with NMDA receptors | Zendy

Jiyuan Zhang | Zendy; Xingang Guan | Zendy; Qin Li | Zendy; Andrea L. Meredith | Zendy; HuiLin Pan | Zendy; Jiusheng Yan | Zendy

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Glutamate-activated BK channel complexes formed with NMDA receptors

Author(s) -

Jiyuan Zhang,

Xingang Guan,

Qin Li,

Andrea L. Meredith,

HuiLin Pan,

Jiusheng Yan

Publication year - 2018

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1802567115

Subject(s) - nmda receptor , glutamate receptor , chemistry , receptor , neuroscience , long term depression , pharmacology , biophysics , ampa receptor , psychology , medicine , biology , biochemistry

Significance Large-conductance BK channels are dually activated by voltage and Ca2+ and play a powerful integrative role in regulating cellular excitability and Ca2+ signaling in neurons. However, BK channels have a requirement of high intracellular free Ca2+ concentrations for activation under physiological conditions, and the Ca2+ sources for their activation are not well understood. In this work, we establish that BK channels physically form protein complexes with Ca2+ -permeable NMDA receptors via their obligatory BKα and GluN1 subunits. The activation mechanism and function of postsynaptic BK channels at synapses remain largely unknown. We found that postsynaptic BK channels in medial perforant path-dentate gyrus granule cell synapses are activated by NMDA receptor-mediated Ca2+ influx and modulate excitatory synaptic transmission.

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