Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell–platelet–monocyte interaction | Zendy

Miruna Popa | Zendy; Sibgha Tahir | Zendy; Julia Elrod | Zendy; Su Hwan Kim | Zendy; Florian Leuschner | Zendy; Thorsten Kessler | Zendy; Peter Bugert | Zendy; Ulrich Pohl | Zendy; Andreas H. Wagner | Zendy; Markus Hecker | Zendy

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Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell–platelet–monocyte interaction

Author(s) -

Miruna Popa,

Sibgha Tahir,

Julia Elrod,

Su Hwan Kim,

Florian Leuschner,

Thorsten Kessler,

Peter Bugert,

Ulrich Pohl,

Andreas H. Wagner,

Markus Hecker

Publication year - 2018

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1801366115

Subject(s) - chemistry , adamts13 , von willebrand factor , platelet , monocyte , cd154 , biophysics , microbiology and biotechnology , cd40 , immunology , in vitro , biology , biochemistry , cytotoxic t cell

Significance In this study we have identified a mechanism that links pathophysiological ADAMTS13 deficiency to innate immunity and hemostasis by facilitating monocyte extravasation as a prerequisite for their subsequent on-site differentiation into proinflammatory macrophages under conditions of both physiological laminar flow and disturbed reduced flow, e.g., as occurs at atherosclerosis predilection sites. Our bioassay approach using patients’ plasma may become a useful diagnostic tool to assess ADAMTS13 activity ex vivo under conditions of near-physiological to atherosclerosis-prone arterial blood flow, which seems to be more relevant than the conventional static FRET-based assay method.

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