Fermentation of dihydroxyacetone by engineered Escherichia coli and Klebsiella variicola to products | Zendy

Liang Wang | Zendy; Diane Chauliac | Zendy; Mun Su Rhee | Zendy; A. Panneerselvam | Zendy; L. O. Ingram | Zendy; K. T. Shanmugam | Zendy

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Fermentation of dihydroxyacetone by engineered Escherichia coli and Klebsiella variicola to products

Author(s) -

Liang Wang,

Diane Chauliac,

Mun Su Rhee,

A. Panneerselvam,

L. O. Ingram,

K. T. Shanmugam

Publication year - 2018

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1801002115

Subject(s) - dihydroxyacetone , fermentation , biochemistry , mixed acid fermentation , klebsiella oxytoca , escherichia coli , lactic acid , chemistry , metabolic engineering , lactic acid fermentation , biology , food science , bacteria , enterobacteriaceae , glycerol , enzyme , gene , genetics

Significance World-wide natural gas production in 2016 was 3.55 trillion cubic meters, and the natural gas flared is estimated to contribute about 350 million tons of CO2 . The global warming potential of CH4 is several orders of magnitude higher than that of CO2 . Upgrading CH4 to chemicals and liquid fuels converts low-cost natural gas to high-value products and traps it from release into atmosphere. Current chemical technology can produce dihydroxyacetone (DHA) from CH4 provided a microorganism can ferment this growth-inhibitory sugar. Here we report metabolically engineered microorganisms that ferment DHA to products. Combining the existing technology of chemical conversion of CH4 to DHA and the fermentation of this sugar is a strategy to transform inexpensive CH4 to chemicals and liquid fuels.

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