Open AccessA genomewide survey of basic helix–loop–helix factors in Drosophila
Author(s) -
Adrian W. Moore,
Sandra Barbel,
Lily Yeh Jan,
Yuh Nung Jan
Publication year - 2000
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.170301897
Subject(s) - basic helix loop helix , biology , enhancer , drosophila melanogaster , mesoderm , genetics , gene , transcription factor , pas domain , computational biology , dna binding protein , embryonic stem cell
The basic helix-loop-helix (bHLH) transcription factors play important roles in the specification of tissue type during the development of animals. We have used the information contained in the recently published genomic sequence of Drosophila melanogaster to identify 12 additional bHLH proteins. By sequence analysis we have assigned these proteins to families defined by Atonal, Hairy-Enhancer of Split, Hand, p48, Mesp, MYC/USF, and the bHLH-Per, Arnt, Sim (PAS) domain. In addition, one single protein represents a unique family of bHLH proteins. mRNA in situ analysis demonstrates that the genes encoding these proteins are expressed in several tissue types but are particularly concentrated in the developing nervous system and mesoderm.
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