Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity | Zendy

Maurizio Bocchetta | Zendy; Ilaria Di Resta | Zendy; Amy Powers | Zendy; Raoul Fresco | Zendy; Alessandra Tosolini | Zendy; Joseph R. Testa | Zendy; Harvey I. Pass | Zendy; Paola Rizzo | Zendy; Michele Carbone | Zendy

Open Access

Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity

Author(s) -

Maurizio Bocchetta,

Ilaria Di Resta,

Amy Powers,

Raoul Fresco,

Alessandra Tosolini,

Joseph R. Testa,

Harvey I. Pass,

Paola Rizzo,

Michele Carbone

Publication year - 2000

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.170207097

Subject(s) - mesothelial cell , mesothelioma , mesothelium , asbestos , transformation (genetics) , virology , virus , biology , mutant , cell culture , simian , malignant transformation , cancer research , pathology , medicine , genetics , gene , materials science , metallurgy

Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the semipermissive infection thought to be characteristic of human cells. Mesothelial cells are uniformly infected but not lysed by SV40, a mechanism related to p53, and undergo cell transformation at an extremely high rate. Exposure of mesothelial cells to asbestos complemented SV40 mutants in transformation. Our data provide a mechanistic explanation for the ability of SV40 to transform mesothelial cells preferentially and indicate that asbestos and SV40 may be cocarcinogens.

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