Open AccessA hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons
Author(s) -
Yaël Perez,
JeanClaude Lacaille
Publication year - 2001
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.161493498
Subject(s) - long term potentiation , neuroscience , excitatory postsynaptic potential , inhibitory postsynaptic potential , postsynaptic potential , synaptic plasticity , metabotropic glutamate receptor , post tetanic potentiation , hippocampal formation , biology , glutamate receptor , chemistry , receptor , biochemistry
Hippocampal inhibitory interneurons play important roles in controlling the excitability and synchronization of pyramidal cells, but whether they express long-term synaptic plasticity that contributes to hippocampal network function remains uncertain. We found that pairing postsynaptic depolarization with theta-burst stimulation induced long-term potentiation (LTP) of putative single-fiber excitatory postsynaptic currents in interneurons. Either postsynaptic depolarization or theta-burst stimulation alone failed to induce LTP. LTP was expressed as a decrease in failure rates and an increase in excitatory postsynaptic current amplitude, independent of N-methyl-d-aspartate receptors, and dependent on metabotropic glutamate receptors subtype 1a. LTP was induced specifically in interneurons in stratum oriens and not in interneurons of stratum radiatum/lacunosum-moleculare. Thus, excitatory synapses onto specific subtypes of inhibitory interneurons express a new form of hebbian LTP that will contribute to hippocampal network plasticity.