Reply to Newman: Quantification of biological aging in young adults is not the same thing as the onset of obesity | Zendy

Daniel W. Belsky | Zendy

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Reply to Newman: Quantification of biological aging in young adults is not the same thing as the onset of obesity

Author(s) -

Daniel W. Belsky

Publication year - 2015

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1518878112

Subject(s) - organism , biological age , disease , organ system , obesity , physiology , medicine , biology , gerontology , pathology , genetics

Newman (1) highlights a challenge faced by studies seeking to measure aging: How to distinguish the process of aging from its causes. This is simple enough when causes originate outside the organism (e.g., environmental toxicants). But what about conditions inside the organism? Are age-related diseases the cause of biological changes in aging? Or is aging the root cause of age-related diseases? Our study (2) attempted to: (i) disentangle aging from age-related disease by studying young people in their 20s and 30s, decades before age-related disease onset; and (ii) disentangle aging from specific pathologies of individual organ systems by tracking coordinated change over time across several different organ systems. We tracked 18 biomarkers of the cardiovascular, metabolic, and immune systems, kidneys, liver, lungs, gums, …

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