Myocardial NF-κB activation is essential for zebrafish heart regeneration | Zendy

Ravi Karra | Zendy; Anne K. Knecht | Zendy; Kazu Kikuchi | Zendy; Kenneth D. Poss | Zendy

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Myocardial NF-κB activation is essential for zebrafish heart regeneration

Author(s) -

Ravi Karra,

Anne K. Knecht,

Kazu Kikuchi,

Kenneth D. Poss

Publication year - 2015

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1511209112

Subject(s) - zebrafish , regeneration (biology) , heart failure , human heart , heart disease , myocyte , mammalian heart , microbiology and biotechnology , nf κb , medicine , biology , cardiology , signal transduction , genetics , gene

Significance Heart failure occurs when the heart cannot pump enough blood to meet the body’s demands. The heart most often weakens through the loss of muscle cells, called cardiomyocytes. Heart failure is a devastating disease, and one possible cure is to replace the lost cardiomyocytes through regeneration. Unlike humans, zebrafish can efficiently regenerate their hearts after injury. Interestingly, zebrafish heart cells are similar to human heart cells at the molecular level. Understanding how zebrafish can regenerate cardiac tissue can help identify regenerative therapies for humans. Here, we find that NF-κB signaling is a link between the injury response and the regenerative program in zebrafish.

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