Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca 2+ influx, not Ca 2+ -exocytosis coupling | Zendy

Joel P. Baumgart | Zendy; Zhenyu Zhou | Zendy; Masato Hara | Zendy; Daniel C. Cook | Zendy; Michael B. Hoppa | Zendy; Timothy A. Ryan | Zendy; Hugh C. Hemmings | Zendy

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Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca ²⁺ influx, not Ca ²⁺ -exocytosis coupling

Author(s) -

Joel P. Baumgart,

Zhenyu Zhou,

Masato Hara,

Daniel C. Cook,

Michael B. Hoppa,

Timothy A. Ryan,

Hugh C. Hemmings

Publication year - 2015

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1500525112

Subject(s) - exocytosis , synaptic vesicle , chemistry , coupling (piping) , isoflurane , vesicle , biophysics , membrane , biochemistry , biology , materials science , organic chemistry , metallurgy

Significance Clarification of the presynaptic actions of general anesthetics is critical to understanding the molecular and cellular mechanisms of their prominent effects on synaptic transmission. We show that the ether anesthetic isoflurane inhibits synaptic vesicle exocytosis through inhibition of presynaptic Ca2+ influx in the absence of significant alteration of the Ca2+ sensitivity of exocytosis. The greater inhibition of glutamate release compared with GABA release is explained by the relative anesthetic resistance of Ca2+ influx in GABAergic boutons, consistent with overall reduction in excitatory synaptic tone.

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