Aptamer photoregulation in vivo | Zendy

Lele Li | Zendy; Rong Tong | Zendy; Hunghao Chu | Zendy; Weiping Wang | Zendy; Róbert Langer | Zendy; Daniel S. Kohane | Zendy

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Aptamer photoregulation in vivo

Author(s) -

Lele Li,

Rong Tong,

Hunghao Chu,

Weiping Wang,

Róbert Langer,

Daniel S. Kohane

Publication year - 2014

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1420105111

Subject(s) - aptamer , in vivo , oligonucleotide , in vitro , chemistry , biophysics , biochemistry , biology , microbiology and biotechnology , dna , genetics

The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation of aptamer activity in vitro and in vivo. Cell binding by the aptamer was prevented by hybridizing the aptamer to a photo-labile complementary oligonucleotide. Upon irradiation at the tumor site, the aptamer was liberated, leading to prolonged intratumoral retention. The relative distribution of the aptamer to the liver and kidney was also significantly decreased, compared to that of the free aptamer.

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