Open AccessReply to Heng: Inborn aneuploidy and chromosomal instability
Author(s) -
Anders Valind,
David Gisselsson
Publication year - 2014
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1323978111
Subject(s) - aneuploidy , chromosome instability , genetics , genome instability , biology , chromosome , dna , dna damage , gene
It is with great interest that we read the letter by Heng (1), who kindly brought up the interesting topic of nonclonal-chromosome aberrations (NCCAs) in the context of our recent report on the relationship between inborn aneuploidy and chromosome instability (CIN). We fully agree with Heng that NCCAs are better proxies for CIN than clonal-chromosome aberrations (CCAs). In fact, we used the frequency of NCCA as proxy to CIN in our study (2). We also agree that it might well be that aneuploidy causes other …
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