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You can read the Nobel Prize Web site for the best description of the science behind the 2013 Nobel Prize in Chemistry. However, let me tell you what the beginnings of the science and its immediate impact were really like–a personal account from a close bystander and indirect collaborator in a neighboring field who grew up scientifically with two of the laureates, and knows well the third. The new laureates' papers in the mid-1970s changed the way we think about proteins and set up a new area of science, which immediately and radically influenced and inspired me, along with many others.

Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 Nobel Laureates in Chemistry