Drosha as an interferon-independent antiviral factor | Zendy

Jillian S. Shapiro | Zendy; Sonja Schmid | Zendy; Lauren C. Aguado | Zendy; Leah R. Sabin | Zendy; Ari Yasunaga | Zendy; Jaehee V. Shim | Zendy; David Sachs | Zendy; Sara Cherry | Zendy; Benjamin R. tenOever | Zendy

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Drosha as an interferon-independent antiviral factor

Author(s) -

Jillian S. Shapiro,

Sonja Schmid,

Lauren C. Aguado,

Leah R. Sabin,

Ari Yasunaga,

Jaehee V. Shim,

David Sachs,

Sara Cherry,

Benjamin R. tenOever

Publication year - 2014

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1319635111

Subject(s) - drosha , biology , virus , rna , viral replication , interferon , virology , nuclease , rnase p , rna virus , microbiology and biotechnology , dna , genetics , rna interference , gene

Significance Virus infections must be combated at a cellular level. The strategies used to inhibit virus differ dramatically when comparing plants and insects to mammals. Here, we identify an evolutionary conserved antiviral response that is independent of these known defenses. We demonstrate that an RNA nuclease called Drosha is repurposed during virus infection to cleave viral RNA and modulate the cellular environment as a means of inhibiting virus replication.

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