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Significance Sensory inputs are known to control aging. The underlying circuitry through which these cues are integrated into regulatory physiological outputs, however, remains largely unknown. Here, we use the taste sensory system of the fruit flyDrosophila melanogaster to detail one such circuit. Specifically, we find that water-sensing taste signals alter nutrient homeostasis and regulate a glucagon-like signaling pathway to govern production of internal water production. This metabolic alteration likely serves as a response to water sensory information. This control of metabolic state, in turn, determines the organism’s long-term health and lifespan. Our studies, then, provide a framework for understanding sensory control of aging as well as several targets to potentially maximize organismal health.

Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling