Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies | Zendy

Joshua Donaldson | Zendy; Cindy Zer | Zendy; Kendra N. Avery | Zendy; K.P. Bzymek | Zendy; David Horne | Zendy; John C. Williams | Zendy

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Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies

Author(s) -

Joshua Donaldson,

Cindy Zer,

Kendra N. Avery,

K.P. Bzymek,

David Horne,

John C. Williams

Publication year - 2013

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1307309110

Subject(s) - monoclonal antibody , complementarity determining region , antigen , linker , peptide , binding site , epidermal growth factor receptor , chemistry , ligand binding assay , microbiology and biotechnology , cetuximab , antibody , computational biology , biology , biochemistry , receptor , immunology , operating system , computer science

Significance The identification and subsequent grafting of a unique peptide binding site within the Fab domain offers a unique means of adding functionality to monoclonal antibodies through a noncovalent interaction including improved pretargeted imaging, alternative payload delivery, and cross-linking of mAbs on cell surfaces to enhance their therapeutic potential.

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