Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer | Zendy

Yong Peng | Zendy; Yuntao Dai | Zendy; Charles L. Hitchcock | Zendy; Xiaojuan Yang | Zendy; Edmund S. Kassis | Zendy; Lunxu Liu | Zendy; Zhenghua Luo | Zendy; Hui-Lung Sun | Zendy; Ri Cui | Zendy; Huijun Wei | Zendy; TaeWan Kim | Zendy; Tae Jin Lee | Zendy; Young-Jun Jeon | Zendy; Gerard J. Nuovo | Zendy; Stefano Volinia | Zendy; Qianchuan He | Zendy; Jianhua Yu | Zendy; Patrick NanaSinkam | Zendy; Carlo M. Croce | Zendy

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Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer

Author(s) -

Yong Peng,

Yuntao Dai,

Charles L. Hitchcock,

Xiaojuan Yang,

Edmund S. Kassis,

Lunxu Liu,

Zhenghua Luo,

Hui-Lung Sun,

Ri Cui,

Huijun Wei,

TaeWan Kim,

Tae Jin Lee,

Young-Jun Jeon,

Gerard J. Nuovo,

Stefano Volinia,

Qianchuan He,

Jianhua Yu,

Patrick NanaSinkam,

Carlo M. Croce

Publication year - 2013

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.1307107110

Subject(s) - microrna , biology , cancer research , insulin like growth factor 1 receptor , insulin like growth factor , lung cancer , cancer , growth factor , suppressor , insulin like growth factor receptor , medicine , receptor , genetics , gene

MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall cell lung cancers (n = 81) and determined that miR-486 was the most down-regulated miRNA in tumors compared with adjacent uninvolved lung tissues, suggesting that miR-486 loss may be important in lung cancer development. We report that miR-486 directly targets components of insulin growth factor (IGF) signaling including insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R), and phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1, or p85a) and functions as a potent tumor suppressor of lung cancer both in vitro and in vivo. Our findings support the role for miR-486 loss in lung cancer and suggest a potential biological link to p53.

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