Open AccessThe Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na + /H + antiporter
Author(s) -
Huazhong Shi,
Manabu Ishitani,
Cheol-Soo Kim,
Jian Kang Zhu
Publication year - 2000
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.120170197
Subject(s) - antiporter , biology , mutant , arabidopsis , transmembrane protein , gene , arabidopsis thaliana , sodium–hydrogen antiporter , transmembrane domain , genetics , microbiology and biotechnology , biochemistry , chemistry , sodium , membrane , receptor , organic chemistry
InArabidopsis thaliana , theSOS1 (S altO verlyS ensitive1 ) locus is essential for Na+ and K+ homeostasis, andsos1 mutations render plants more sensitive to growth inhibition by high Na+ and low K+ environments.SOS1 is cloned and predicted to encode a 127-kDa protein with 12 transmembrane domains in the N-terminal part and a long hydrophilic cytoplasmic tail in the C-terminal part. The transmembrane region of SOS1 has significant sequence similarities to plasma membrane Na+ /H+ antiporters from bacteria and fungi. Sequence analysis of varioussos1 mutant alleles reveals several residues and regions in the transmembrane as well as the tail parts that are critical for SOS1 function in plant salt tolerance.SOS1 gene expression in plants is up-regulated in response to NaCl stress. This up-regulation is abated insos3 orsos2 mutant plants, suggesting that it is controlled by the SOS3/SOS2 regulatory pathway.