A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-β signaling | Zendy

Kiyokazu Morita | Zendy; Miho Shimizu | Zendy; Hiroshi Shibuyà | Zendy; Naoto Ueno | Zendy

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A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-β signaling

Author(s) -

Kiyokazu Morita,

Miho Shimizu,

Hiroshi Shibuyà,

Naoto Ueno

Publication year - 2001

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.111409798

Subject(s) - caenorhabditis elegans , biology , gene product , transforming growth factor beta , microbiology and biotechnology , signal transduction , phenotype , receptor , acvrl1 , transforming growth factor , gene , regulator , mutation , decay accelerating factor , fusion protein , genetics , gene expression , endoglin , recombinant dna , antibody , complement system , stem cell , cd34

We have identified homologs of a human BMP receptor-associated molecule BRAM1 in Caenorhabditis elegans. One of them, BRA-1, has been found to bind DAF-1, the type I receptor in the DAF-7 transforming growth factor-beta pathway through the conserved C-terminal region. As analyzed using a BRA-1GFP (green fluorescent protein) fusion gene product, the bra-1 gene is expressed in amphid neurons such as ASK, ASI, and ASG, where daf-1 is also expressed. A loss-of-function mutation in bra-1 exhibits robust suppression of the Daf-c phenotype caused by the DAF-7 pathway mutations. We propose that BRA-1 represents a novel class of receptor-associated molecules that negatively regulate transforming growth factor-beta pathways.

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