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We read with great interest the recent PNAS report by Kross et al. (1). In this study, the authors selected a population of volunteers who recently experienced an unwanted breakup of their love relationship, and used functional MRI (fMRI) to record the brain responses elicited by (i) observing a photograph of their ex-partner as they think about being rejected and (ii) receiving actual nociceptive somatosensory simulation. Based on the observation of an “overlap between social rejection and physical pain[...] areas”, assumed to “support the sensory components of physical pain (secondary somatosensory cortex; dorsal posterior insula)”, …

Can the functional MRI responses to physical pain really tell us why social rejection “hurts”?