Open AccessSuppressor of gamma response 1 ( SOG1 ) encodes a putative transcription factor governing multiple responses to DNA damage
Author(s) -
Kaoru Yoshiyama,
Phillip A. Conklin,
Neil D. Huefner,
Anne Britt
Publication year - 2009
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0810304106
Subject(s) - arabidopsis , biology , transcription factor , mutant , dna damage , gene , genetics , suppressor , microbiology and biotechnology , transcription (linguistics) , dna repair , arabidopsis thaliana , dna , linguistics , philosophy
TheArabidopsis sog1-1 (suppressor of gamma response) mutant was originally isolated as a second-site suppressor of the radiosensitive phenotype of seeds defective in the repair endonuclease XPF. Here, we report thatSOG1 encodes a putative transcription factor. This gene is a member of the NAC domain [petuniaNAM (no apical meristem) and ArabidopsisATAF1 , 2 andCUC2 ] family (a family of proteins unique to land plants). Hundreds of genes are normally up-regulated inArabidopsis within an hour of treatment with ionizing radiation; the induction of these genes requires the damage response protein kinase ATM, but not the related kinase ATR. Here, we find thatSOG1 is also required for this transcriptional up-regulation. In contrast, theSOG1 -dependent checkpoint response observed inxpf mutant seeds requiresATR , but does not requireATM . Thus, phenotype of thesog1-1 mutant mimics aspects of the phenotypes of bothatr andatm mutants in Arabidopsis, suggesting thatSOG1 participates in pathways governed by both of these sensor kinases. We propose that, in plants, signals related to genomic stress are processed through a single, central transcription factor,SOG1 .