Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores | Zendy

Geeta G. Sharma | Zendy; Sukumar Vijayaraghavan | Zendy

Open Access

Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores

Author(s) -

Geeta G. Sharma,

Sukumar Vijayaraghavan

Publication year - 2001

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.071540198

Subject(s) - calcium , cholinergic , calcium in biology , nicotinic agonist , hippocampal formation , intracellular , acetylcholine receptor , microbiology and biotechnology , acetylcholine , receptor , neuroscience , t type calcium channel , calcium signaling , biology , chemistry , voltage dependent calcium channel , endocrinology , biochemistry , organic chemistry

In this report we provide evidence that neuronal nicotinic acetylcholine receptors (nAChRs) are present on hippocampal astrocytes and their activation produces rapid currents and calcium transients. Our data indicate that these responses obtained from astrocytes are primarily mediated by an AChR subtype that is functionally blocked by alpha-bungarotoxin (alpha Bgt) and contains the alpha7 subunit (alpha Bgt-AChRs). Furthermore, their action is unusual in that they effectively increase intracellular free calcium concentrations by activating calcium-induced calcium release from intracellular stores, triggered by influx through the receptor channels. These results reveal a mechanism by which alpha Bgt-AChRs on astrocytes can efficiently modulate calcium signaling in the central nervous system in a manner distinct from that observed with these receptors on neurons.

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