Universal scaling law of electrical turbulence in the mammalian heart | Zendy

Sami F. Noujaim | Zendy; Omer Berenfeld | Zendy; Jérôme Kalifa | Zendy; Marina Cerrone | Zendy; Kumaraswamy Nanthakumar | Zendy; Felipe Atienza | Zendy; Javier Moreno | Zendy; Sergey Mironov | Zendy; José Jalife | Zendy

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Universal scaling law of electrical turbulence in the mammalian heart

Author(s) -

Sami F. Noujaim,

Omer Berenfeld,

Jérôme Kalifa,

Marina Cerrone,

Kumaraswamy Nanthakumar,

Felipe Atienza,

Javier Moreno,

Sergey Mironov,

José Jalife

Publication year - 2007

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.0709758104

Subject(s) - scaling , exponent , scaling law , turbulence , allometry , ventricular fibrillation , physics , optical mapping , statistical physics , biology , cardiology , mechanics , mathematics , medicine , geometry , ecology , philosophy , linguistics

Many biological processes, such as metabolic rate and life span, scale with body mass (BM) according to the universal law of allometric scaling: Y = aBM(b) (Y, biological process; b, scaling exponent). We investigated whether the temporal properties of ventricular fibrillation (VF), the major cause of sudden and unexpected cardiac death, scale with BM. By using high-resolution optical mapping, numerical simulations and metaanalysis of VF data in 11 mammalian species, we demonstrate that the interbeat interval of VF scales as VF(cycle) (length) = 53 x BM(1/4), spanning more than four orders of magnitude in BM from mouse to horse.

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