Open AccessWhat's the point of the type III secretion system needle?
Author(s) -
Ariel Blocker,
Janet E. Deane,
Andreas K. J. Veenendaal,
Pietro Roversi,
J. Hodgkinson,
Steven Johnson,
Susan M. Lea
Publication year - 2008
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0708344105
Subject(s) - secretion , type three secretion system , function (biology) , type (biology) , perspective (graphical) , extracellular , biology , computational biology , key (lock) , microbiology and biotechnology , computer science , mutant , biochemistry , ecology , artificial intelligence , gene
Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretion system (T3SS) of Gram-negative bacteria. This perspective presents a structure-informed analysis of functional data and discusses three nonmutually exclusive models of how a key aspect of T3SS biology, the sensing of host cells, may be performed.