Open AccessHomeostatic regulation of AMPA receptor expression at single hippocampal synapses
Author(s) -
Qingming Hou,
Dawei Zhang,
Larissa A. Jarzylo,
Richard L. Huganir,
Heng Ye Man
Publication year - 2008
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0706447105
Subject(s) - homeostatic plasticity , synaptic scaling , ampa receptor , metaplasticity , synaptic plasticity , neuroscience , synapse , glutamate receptor , homeostasis , biology , hippocampal formation , nmda receptor , synaptic fatigue , receptor , microbiology and biotechnology , biochemistry
Homeostatic synaptic response is an important measure in confining neuronal activity within a narrow physiological range. Whether or not homeostatic plasticity demonstrates synapse specificity, a key feature characteristic of Hebbian-type plasticity, is largely unknown. Here, we report that in cultured hippocampal neurons, α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid subtype glutamate receptor (AMPAR) accumulation is increased selectively in chronically inhibited single synapses, whereas the neighboring normal synapses remain unaffected. This synapse-specific homeostatic regulation depends on the disparity of synaptic activity and is mediated by GluR2-lacking AMPARs and PI3-kinase signaling. These results demonstrate the existence of synaptic specificity and the crucial role of AMPAR-gated calcium in homeostatic plasticity in central neurons.