Open AccessInhibition of the cytokine response does not protect against lethal H5N1 influenza infection
Author(s) -
Rachelle Salomon,
Erich Hoffmann,
Robert G. Webster
Publication year - 2007
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0705289104
Subject(s) - proinflammatory cytokine , cytokine storm , cytokine , influenza a virus subtype h5n1 , immunology , chemokine , influenza a virus , virus , biology , virology , tumor necrosis factor alpha , inflammation , medicine , covid-19 , infectious disease (medical specialty) , disease
Because proinflammatory cytokines are markedly elevated during H5N1 influenza virus infection, the "cytokine storm" is hypothesized to be the main cause of mortality. Here, we demonstrate that mice deficient in the hallmark inflammatory cytokines TNF-alpha, IL-6, or CC chemokine ligand 2 succumb to infection with A/Vietnam/1203/04 (H5N1) virus, as do wild-type mice treated with glucocorticoids for suppression of cytokines. Because cytokine inhibition does not protect against death, therapies that target the virus rather than cytokines may be preferable.
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