Open AccessEvidence of spatially bound gene regulation in Mus musculus : Decreased gene expression proximal to microRNA genomic location
Author(s) -
Hidenori Inaoka,
Yutaka Fukuoka,
Isaac S. Kohane
Publication year - 2007
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0611078104
Subject(s) - caenorhabditis elegans , biology , microrna , gene , regulation of gene expression , gene expression , genetics , cpg site , transcription factor , messenger rna , dna methylation
The extent, spatially and in time, of the phenomenon of localized decreased expression in the chromosomal vicinity of microRNA (miRNA) previously described inCaenorhabditis elegans is reproduced inMus musculus across a wide range of tissues in several independent experiments. Computationally predicted miRNA targets are enriched in the vicinity of miRNAs, and transcription factors are identified as the class of genes that systematically exhibit this localized decrease. Also, those mRNA with AT-rich UTRs, particularly those that are not in the vicinity of CpG islands, most often exhibit this localized decrease. This localization broadens with the shift from developing to mature/differentiated tissues and suggests a developmentally controlled and spatially bound regulation.