Open AccessTORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity
Author(s) -
Krisztián A. Kovács,
Pascal Steullet,
Myriam Steinmann,
Kim Q.,
Pierre J. Magistretti,
Olivier Halfon,
JeanRené Cardinaux
Publication year - 2007
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0607524104
Subject(s) - long term potentiation , creb , neuronal memory allocation , synaptic plasticity , neuroscience , coincidence detection in neurobiology , metaplasticity , schaffer collateral , neurotransmission , biology , microbiology and biotechnology , transcription factor , chemistry , medicine , genetics , gene , receptor , coincidence , alternative medicine , pathology
A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral–CA1 synapses in the hippocampus.