Open AccessImaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography
Author(s) -
Ben Brooksby,
Brian W. Pogue,
Shudong Jiang,
Hamid Dehghani,
Subhadra Srinivasan,
Christine Kogel,
Tor D. Tosteson,
John B. Weaver,
Steven P. Poplack,
Keith D. Paulsen
Publication year - 2006
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0509636103
Subject(s) - adipose tissue , magnetic resonance imaging , tomography , nuclear magnetic resonance , materials science , nuclear medicine , pathology , medicine , chemistry , radiology , biomedical engineering , physics
Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom