Open AccessTbx6-mediated Notch signaling controls somite-specific Mesp2 expression
Author(s) -
Yukuto Yasuhiko,
Satoru Haraguchi,
Satoshi Kitajima,
Yu Takahashi,
Jun Kanno,
Yumiko Saga
Publication year - 2006
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0508238103
Subject(s) - somitogenesis , paraxial mesoderm , somite , notch signaling pathway , microbiology and biotechnology , transcription factor , mesoderm , biology , genetics , signal transduction , gene , embryonic stem cell , embryogenesis , embryo
Mesp2 is a transcription factor that plays fundamental roles in somitogenesis, and its expression is strictly restricted to the anterior presomitic mesoderm just before segment border formation. The transcriptional on–off cycle is linked to the segmentation clock. In our current study, we show that a T-box transcription factor, Tbx6, is essential forMesp2 expression. Tbx6 directly binds to theMesp2 gene upstream region and mediates Notch signaling, and subsequentMesp2 transcription, in the anterior presomitic mesoderm. Our data therefore reveal that a mechanism, via Tbx6-dependent Notch signaling, acts on the transcriptional regulation ofMesp2 . This finding uncovers an additional component of the interacting network of various signaling pathways that are involved in somitogenesis.