Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys | Zendy

Janita Turchi | Zendy; Richard C. Saunders | Zendy; Mortimer Mishkin | Zendy

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Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys

Author(s) -

Janita Turchi,

Richard C. Saunders,

Mortimer Mishkin

Publication year - 2005

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.0409708102

Subject(s) - cholinergic , neuroscience , immunotoxin , visual cortex , cortex (anatomy) , cerebral cortex , perirhinal cortex , recognition memory , psychology , biology , cognition , monoclonal antibody , antibody , immunology

Excitotoxic lesion studies have confirmed that the rhinal cortex is essential for visual recognition ability in monkeys. To evaluate the mnemonic role of cholinergic inputs to this cortical region, we compared the visual recognition performance of monkeys given rhinal cortex infusions of a selective cholinergic immunotoxin, ME20.4-SAP, with the performance of monkeys given control infusions into this same tissue. The immunotoxin, which leads to selective cholinergic deafferentation of the infused cortex, yielded recognition deficits of the same magnitude as those produced by excitotoxic lesions of this region, providing the most direct demonstration to date that cholinergic activation of the rhinal cortex is essential for storing the representations of new visual stimuli and thereby enabling their later recognition.

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