Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice | Zendy

Daniel J. Liebl | Zendy; Laura J. Klesse | Zendy; Lino Tessarollo | Zendy; Todd Wohlman | Zendy; Luis F. Parada | Zendy

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Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice

Author(s) -

Daniel J. Liebl,

Laura J. Klesse,

Lino Tessarollo,

Todd Wohlman,

Luis F. Parada

Publication year - 2000

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.040562597

Subject(s) - neuroscience , tropomyosin receptor kinase b , brain derived neurotrophic factor , neurotrophin , sensory system , neurotrophic factors , tropomyosin receptor kinase a , neurotrophin 3 , nerve growth factor , biology , proprioception , sensory neuron , receptor , genetics

Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports survival of neurons that differentiate primarily into proprioceptors whereas nerve growth factor and brain-derived neurotrophic factor (BDNF) support subpopulations that transmit nociception and mechanoreception, respectively. We examined sensory neurons of gene-targeted mouse mutants at the NT-4, BDNF, NT-3, and TrkA loci. We show that NT-4 functions early in gangliogenesis, upstream of BDNF. In the absence of NT-4 function, BDNF-dependent, TrkB-expressing neurons fail to appear. The results are consistent with the model that precursor cells intended to become BDNF-dependent mechanoreceptors instead differentiate into NT-3-dependent proprioceptive neurons.

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