The essence of total synthesis | Zendy

K. C. Nicolaou | Zendy; Scott A. Snyder | Zendy

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The essence of total synthesis

Author(s) -

K. C. Nicolaou,

Scott A. Snyder

Publication year - 2004

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.0403799101

Subject(s) - principal (computer security) , biochemical engineering , perspective (graphical) , natural (archaeology) , reactivity (psychology) , synthetic biology , power (physics) , data science , computer science , computational biology , biology , engineering , medicine , artificial intelligence , computer security , alternative medicine , physics , paleontology , pathology , quantum mechanics

For the past century, the total synthesis of natural products has served as the flagship of chemical synthesis and the principal driving force for discovering new chemical reactivity, evaluating physical organic theories, testing the power of existing synthetic methods, and enabling biology and medicine. This perspective article seeks to examine this time-honored and highly demanding art, distilling its essence in an effort to ascertain its power and future potential.

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