Open AccessSynthesis of the thapsigargins
Author(s) -
Steven V. Ley,
Alessandra Antonello,
Emily P. Balskus,
David T. Booth,
Søren Brøgger Christensen,
Ed Cleator,
Helen Gold,
Klemens Högenauer,
Udo Hünger,
R. M. Myers,
Steven F. Oliver,
Oliver Simić,
Martin D. Smith,
Helmer Søhoel,
Alison J.-A. Woolford
Publication year - 2004
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0403300101
Subject(s) - skeleton (computer programming) , combinatorial chemistry , synthetic biology , computational biology , natural (archaeology) , chemistry , computer science , stereochemistry , biology , programming language , paleontology
The thapsigargins are a family of complex guaianolides with potent and selective Ca(2+)-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.