Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases | Zendy

Junji Yamauchi | Zendy; Jonah R. Chan | Zendy; Eric M. Shooter | Zendy

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Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases

Author(s) -

Junji Yamauchi,

Jonah R. Chan,

Eric M. Shooter

Publication year - 2004

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.0402795101

Subject(s) - rhoa , microbiology and biotechnology , neurotrophin , cdc42 , biology , guanine nucleotide exchange factor , rac1 , signal transduction , cell migration , schwann cell , gtpase , neurotrophic factors , low affinity nerve growth factor receptor , neuroscience , receptor , cell , biochemistry

Neurotrophins are recognized widely as essential factors in the developing nervous system. Previously, we demonstrated that neurotrophin 3 activation of TrkC inhibits Schwann cell myelination and enhances the migration of primary Schwann cells through the signaling pathway regulated by the Rho GTPases Rac1 and Cdc42. Here, we show that neurotrophins activate divergent signaling pathways to promote or inhibit Schwann cell migration. Endogenous brain-derived neurotrophic factor acting through p75(NTR) inhibits Schwann cell migration dramatically by Src kinase-dependent activation of the guanine-nucleotide exchange factor Vav2 and RhoA. Together, these results suggest that neurotrophins and their receptors differentially regulate Schwann cell migration through the signaling pathways that depend on Rho GTPases.

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