Critical roles of interferon regulatory factor 4 in CD11bhighCD8α–dendritic cell development | Zendy

Shoichi Suzuki | Zendy; Kiri Honma | Zendy; T. Matsuyama | Zendy; Kazuo Suzuki | Zendy; Kan Toriyama | Zendy; Ichinose Akitoyo | Zendy; Kazuo Yamamoto | Zendy; Takashi Suematsu | Zendy; Michio Nakamura | Zendy; Katsuyuki Yui | Zendy; Atsushi Kumatori | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Critical roles of interferon regulatory factor 4 in CD11b^highCD8α^–dendritic cell development

Author(s) -

Shoichi Suzuki,

Kiri Honma,

T. Matsuyama,

Kazuo Suzuki,

Kan Toriyama,

Ichinose Akitoyo,

Kazuo Yamamoto,

Takashi Suematsu,

Michio Nakamura,

Katsuyuki Yui,

Atsushi Kumatori

Publication year - 2004

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.0402139101

Subject(s) - cd8 , irf8 , microbiology and biotechnology , spleen , immune system , biology , interferon regulatory factors , dendritic cell , transcription factor , immunology , integrin alpha m , innate immune system , genetics , gene

IFN regulatory factors (IRFs) are a family of transcription factors that play an essential role in the homeostasis and function of immune systems. Recent studies indicated that IRF-8 is critical for the development of CD11b(low)CD8alpha(+) conventional dendritic cells (DCs) and plasmacytoid DCs. Here we show that IRF-4 is important for CD11b(high)CD8alpha(-) conventional DCs. The development of CD11b(high) DCs from bone marrow of IRF-4(-/-) mice was severely impaired in two culture systems supplemented with either GM-CSF or Flt3-ligand. In the IRF-4(-/-) spleen, the number of CD4(+)CD8alpha(-) DCs, a major subset of CD11b(high) DCs, was severely reduced. IRF-4 and IRF-8 were expressed in the majority of CD11b(high)CD4(+)CD8alpha(-) DCs and CD11b(low)CD8alpha(+) DCs, respectively, in a mutually exclusive manner. These results imply that IRF-4 and IRF-8 selectively play critical roles in the development of the DC subsets that express them.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research