Open AccessOligomeric catechins: An enabling synthetic strategy by orthogonal activation and C(8) protection
Author(s) -
Ken Ohmori,
Naoko Ushimaru,
Keisuke Suzuki
Publication year - 2004
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0401651101
Subject(s) - catechin , chemistry , electrophile , polyphenol , flavan , combinatorial chemistry , nucleophile , stereochemistry , biochemistry , catalysis , antioxidant
Controlled formation of oligomeric catechins has become possible by an orthogonal synthetic strategy. Bromo-capping of the C(8) position of the flavan skeleton enabled the equimolar coupling of electrophilic and nucleophilic catechin derivatives, enabling an efficient synthetic strategy to complex catechin oligomers.