Proteomic mapping provides powerful insights into functional myelin biology | Zendy

Christopher M. Taylor | Zendy; Cecilia B. Marta | Zendy; Robert Claycomb | Zendy; David K. Han | Zendy; Matthew N. Rasband | Zendy; Timothy Coetzee | Zendy; S. E. Pfeiffer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Proteomic mapping provides powerful insights into functional myelin biology

Author(s) -

Christopher M. Taylor,

Cecilia B. Marta,

Robert Claycomb,

David K. Han,

Matthew N. Rasband,

Timothy Coetzee,

S. E. Pfeiffer

Publication year - 2004

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.0400922101

Subject(s) - cytoarchitecture , myelin , proteomics , biology , peptide mapping , proteome , two dimensional gel electrophoresis , computational biology , membrane protein , gel electrophoresis , microbiology and biotechnology , neuroscience , bioinformatics , biochemistry , central nervous system , peptide sequence , membrane , gene

Myelin is a dynamic, functionally active membrane necessary for rapid action potential conduction, axon survival, and cytoarchitecture. The number of debilitating neurological disorders that occur when myelin is disrupted emphasizes its importance. Using high-resolution 2D gel electrophoresis, mass spectrometry, and immunoblotting, we have developed an extensive proteomic map of proteins present in myelin, identifying 98 proteins corresponding to at least 130 of the approximately 200 spots on the map. This proteomic map has been applied to analyses of the localization and function of selected proteins, providing a powerful tool to investigate the diverse functions of myelin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research