Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection | Zendy

Santosh Kumar Chaubey | Zendy; Ashim Sinha | Zendy; Elizabeth Phillips | Zendy; Darren Russell | Zendy; Henrik Falhammar | Zendy

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Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection

Author(s) -

Santosh Kumar Chaubey,

Ashim Sinha,

Elizabeth Phillips,

Darren Russell,

Henrik Falhammar

Publication year - 2009

Publication title -

sexual health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.117

H-Index - 43

eISSN - 1449-8987

pISSN - 1448-5028

DOI - 10.1071/sh09005

Subject(s) - medicine , ritonavir , lopinavir/ritonavir , lopinavir , cardiology , sick sinus syndrome , lamivudine , junctional rhythm , sinus rhythm , electrocardiography , anesthesia , human immunodeficiency virus (hiv) , virology , atrial fibrillation , viral load , antiretroviral therapy , virus , hepatitis b virus

A 42-year-old Thai man was administered the combination drugs liponavir/ritonavir and abacavir/lamivudine. On day 3 he was admitted and his electrocardiogram demonstrated sinus arrest with junctional escape rhythm with a rate of 42 min(-1). Three days after stopping the medication he reverted to normal sinus rhythm. A 55-year-old Caucasian man was admitted to hospital with triple vessel disease. He had a permanent pacemaker inserted 4 years previously for Mobitz type II AV block detected on stress electrocardiogram, which developed 1 month after initiation of lopinavir/ritonavir. These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.

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