Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives | Zendy

Rehmani N. Muhammad | Zendy; Ee Ling Chang | Zendy; Alistair G. Draffan | Zendy; Anthony C. Willis | Zendy; Paul D. Carr | Zendy; Martin G. Banwell | Zendy

Open Access

Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives

Author(s) -

Rehmani N. Muhammad,

Ee Ling Chang,

Alistair G. Draffan,

Anthony C. Willis,

Paul D. Carr,

Martin G. Banwell

Publication year - 2018

Publication title -

australian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.319

H-Index - 77

eISSN - 1445-0038

pISSN - 0004-9425

DOI - 10.1071/ch18145

Subject(s) - biocatalysis , chemistry , natural product , alkylation , macromolecule , combinatorial chemistry , substrate (aquarium) , biological activity , stereochemistry , green chemistry , core (optical fiber) , organic chemistry , reaction mechanism , catalysis , biochemistry , in vitro , biology , ecology , materials science , composite material

A range of structural variations on the tricarbocyclic core 2 of the anti-bacterial agent platencin 1, including those represented by compounds 14, 15, and 27, have been prepared and certain of these elaborated, through substrate-controlled enolate alkylation reactions, to analogues of the natural product. Preliminary biological evaluation of these analogues revealed that they are only weakly active anti-infective agents.

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