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Hepatocytes are parenchymal cells of the liver responsible for drug detoxification, urea and bile production, serum protein synthesis, and glucose homeostasis. Hepatocytes are widely used for drug toxicity studies in bioartificial liver devices and for cell-based liver therapies. Because hepatocytes are highly differentiated cells residing in a complex microenvironment  in vivo , they tend to lose hepatic phenotype and function  in vitro . This paper first reviews traditional culture approaches used to rescue hepatic function  in vitro  and then discusses the benefits of emerging microfluidic-based culture approaches. We conclude by reviewing integration of hepatocyte cultures with bioanalytical or sensing approaches.

Hepatocyte cultures: From collagen gel sandwiches to microfluidic devices with integrated biosensors