Recent advancements in enzyme-mediated crosslinkable hydrogels: In vivo-mimicking strategies | Zendy

Wonmoon Song | Zendy; Junghyeon Ko | Zendy; Young Hwan Choi | Zendy; Nathaniel S. Hwang | Zendy

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Recent advancements in enzyme-mediated crosslinkable hydrogels: In vivo-mimicking strategies

Author(s) -

Wonmoon Song,

Junghyeon Ko,

Young Hwan Choi,

Nathaniel S. Hwang

Publication year - 2021

Publication title -

apl bioengineering

Language(s) - English

Resource type - Journals

ISSN - 2473-2877

DOI - 10.1063/5.0037793

Subject(s) - self healing hydrogels , biocompatibility , biomaterial , nanotechnology , tissue engineering , in vivo , materials science , enzyme , function (biology) , biochemical engineering , chemistry , engineering , biomedical engineering , biochemistry , biology , microbiology and biotechnology , polymer chemistry , metallurgy

Enzymes play a central role in fundamental biological processes and have been traditionally used to trigger various processes. In recent years, enzymes have been used to tune biomaterial responses and modify the chemical structures at desired sites. These chemical modifications have allowed the fabrication of various hydrogels for tissue engineering and therapeutic applications. This review provides a comprehensive overview of recent advancements in the use of enzymes for hydrogel fabrication. Strategies to enhance the enzyme function and improve biocompatibility are described. In addition, we describe future opportunities and challenges for the production of enzyme-mediated crosslinkable hydrogels.

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