Serial integration of Dean-structured sample cores with linear inertial focussing for enhanced particle and cell sorting | Zendy

Paul M. Holloway | Zendy; Jonathan Butement | Zendy; Manjunath Hegde | Zendy; Jonathan West | Zendy

Open Access

Serial integration of Dean-structured sample cores with linear inertial focussing for enhanced particle and cell sorting

Author(s) -

Paul M. Holloway,

Jonathan Butement,

Manjunath Hegde,

Jonathan West

Publication year - 2018

Publication title -

biomicrofluidics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 63

ISSN - 1932-1058

DOI - 10.1063/1.5038965

Subject(s) - sorting , inertial frame of reference , particle (ecology) , sample (material) , channel (broadcasting) , computer science , biological system , nanotechnology , physics , materials science , algorithm , classical mechanics , telecommunications , biology , ecology , thermodynamics

In this contribution, a channel aspect ratio of >2 was used to access high velocity regimes to provide confined sample cores by Dean focussing in advance of linear inertial focussing. This produces a singular separation origin with a mirrored transport path for efficient particle and blood cell sorting, while also increasing the spatial resolution for multiscale sorting.

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