Variations in OHC-generated voltage and DPOAEs with low EP | Zendy

Yi Wang | Zendy; Elika Fallah | Zendy; Elizabeth S. Olson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Variations in OHC-generated voltage and DPOAEs with low EP

Author(s) -

Yi Wang,

Elika Fallah,

Elizabeth S. Olson

Publication year - 2018

Publication title -

aip conference proceedings

Language(s) - English

Resource type - Conference proceedings

eISSN - 1551-7616

pISSN - 0094-243X

DOI - 10.1063/1.5038479

Subject(s) - endocochlear potential , hair cell , furosemide , materials science , voltage , gerbil , transducer , voltage drop , cochlea , acoustics , chemistry , audiology , physics , electrical engineering , medicine , engineering , organic chemistry , ischemia

Endocochlear potential (EP) is essential for cochlear amplification, by providing the voltage drop needed to drive outer hair cell (OHC) transducer current, which leads to OHC electromechanical force. An early study using furosemide to reversibly reduce EP showed that distortion product oto-acoustic emissions (DPOAEs) recovered before EP. This indicated that cochlear amplification may be able to adjust to a new, lower EP. To investigate the mechanism of this adjustment, EP and locally-measured OHC-generated voltage were measured simultaneously in gerbil, with intraperitoneal injection of furosemide to reduce EP.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research