On-chip microfluid induced by oscillation of microrobot for noncontact cell transportation | Zendy

Lin Feng | Zendy; Shuzhang Liang | Zendy; Xiangcong Zhou | Zendy; Jianlei Yang | Zendy; Yonggang Jiang | Zendy; Deyuan Zhang | Zendy; Fumihito Arai | Zendy

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On-chip microfluid induced by oscillation of microrobot for noncontact cell transportation

Author(s) -

Lin Feng,

Shuzhang Liang,

Xiangcong Zhou,

Jianlei Yang,

Yonggang Jiang,

Deyuan Zhang,

Fumihito Arai

Publication year - 2017

Publication title -

applied physics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.182

H-Index - 442

eISSN - 1077-3118

pISSN - 0003-6951

DOI - 10.1063/1.5009545

Subject(s) - oscillation (cell signaling) , microfluidics , chip , vortex , microfluidic chip , rotation (mathematics) , materials science , nanotechnology , energy (signal processing) , position (finance) , amplitude , acoustics , optoelectronics , electrical engineering , mechanics , physics , engineering , computer science , chemistry , optics , biochemistry , finance , quantum mechanics , artificial intelligence , economics

The importance of cell manipulation and cultivation is increasing rapidly in various fields, such as drug discovery, regenerative medicine, and investigation of new energy sources. This paper presents a method to transport cells in a microfluidic chip without contact. A local vortex was generated when high-frequency oscillation of a microtool was induced in a microfluidic chip. The vortex was controlled by tuning the tool's oscillation parameters, such as the oscillation amplitude and frequency. The cells were then transported in the chip based on the direction of the tool's movement, and their position, posture, and trajectories were controlled. Bovine oocyte manipulations, that is, transportation and rotation, were conducted to demonstrate the capability of the proposed method, without any contact by the microrobot with high-frequency oscillation.

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