Magnetically targeted delivery through cartilage | Zendy

Sahar Jafari | Zendy; Lamar O. Mair | Zendy; Sagar Chowdhury | Zendy; Alek Nacev | Zendy; Ryan Hilaman | Zendy; P.Yu. Stepanov | Zendy; James Baker-McKee | Zendy; Said Ijanaten | Zendy; Christian Koudelka | Zendy; Bradley English | Zendy; Pulkit Malik | Zendy; I. Weinberg | Zendy

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Magnetically targeted delivery through cartilage

Author(s) -

Sahar Jafari,

Lamar O. Mair,

Sagar Chowdhury,

Alek Nacev,

Ryan Hilaman,

P.Yu. Stepanov,

James Baker-McKee,

Said Ijanaten,

Christian Koudelka,

Bradley English,

Pulkit Malik,

I. Weinberg

Publication year - 2017

Publication title -

aip advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.421

H-Index - 58

ISSN - 2158-3226

DOI - 10.1063/1.5006156

Subject(s) - cartilage , magnetic nanoparticles , materials science , osteoarthritis , magnet , magnetic field , biomedical engineering , nuclear magnetic resonance , articular cartilage , magnetostatics , nanoparticle , nanotechnology , anatomy , medicine , pathology , physics , alternative medicine , quantum mechanics

In this study, we have invented a method of delivering drugs deep into articular cartilage with shaped dynamic magnetic fields acting on small metallic magnetic nanoparticles with polyethylene glycol coating and average diameter of 30 nm. It was shown that transport of magnetic nanoparticles through the entire thickness of bovine articular cartilage can be controlled by a combined alternating magnetic field at 100 Hz frequency and static magnetic field of 0.8 tesla (T) generated by 1" dia. x 2" thick permanent magnet. Magnetic nanoparticles transport through bovine articular cartilage samples was investigated at various settings of magnetic field and time durations. Combined application of an alternating magnetic field and the static field gradient resulted in a nearly 50 times increase in magnetic nanoparticles transport in bovine articular cartilage tissue as compared with static field conditions. This method can be applied to locally deliver therapeutic-loaded magnetic nanoparticles deep into articular cartilage to prevent cartilage degeneration and promote cartilage repair in osteoarthritis.In this study, we have invented a method of delivering drugs deep into articular cartilage with shaped dynamic magnetic fields acting on small metallic magnetic nanoparticles with polyethylene glycol coating and average diameter of 30 nm. It was shown that transport of magnetic nanoparticles through the entire thickness of bovine articular cartilage can be controlled by a combined alternating magnetic field at 100 Hz frequency and static magnetic field of 0.8 tesla (T) generated by 1" dia. x 2" thick permanent magnet. Magnetic nanoparticles transport through bovine articular cartilage samples was investigated at various settings of magnetic field and time durations. Combined application of an alternating magnetic field and the static field gradient resulted in a nearly 50 times increase in magnetic nanoparticles transport in bovine articular cartilage tissue as compared with static field conditions. This method can be applied to locally deliver therapeutic-loaded magnetic nanoparticles deep into articular...

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