Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening | Zendy

Mikhail Mazurenka | Zendy; Lea Behrendt | Zendy; Merve MeinhardtWollweber | Zendy; Uwe Morgner | Zendy; Bernhard Roth | Zendy

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Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

Author(s) -

Mikhail Mazurenka,

Lea Behrendt,

Merve MeinhardtWollweber,

Uwe Morgner,

Bernhard Roth

Publication year - 2017

Publication title -

review of scientific instruments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.605

H-Index - 165

eISSN - 1089-7623

pISSN - 0034-6748

DOI - 10.1063/1.5004999

Subject(s) - raman spectroscopy , optical coherence tomography , optics , in vivo , materials science , confocal , skin cancer , raman scattering , biomedical engineering , cancer , medicine , physics , microbiology and biotechnology , biology

A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo, further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening.

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